邓桂芳，副主任医师，硕士研究生导师，博士后合作导师，华中科技大学协和深圳医院临床营养科副主任（主持工作），东部战区总医院解放军普通外科研究所临床医学博士后，中山大学营养与食品卫生学博士，中华医学会肠外与肠内营养分会世界营养日协作组副组长，中国医师协会外科医师分会临床营养专家工作组专家委员，广东省营养学会理事，广东省医院协会医院营养管理协会副主任委员，广东省营养学会医学营养食品专家组成员，广东省医学会肠外肠内营养分会青年委员，深圳市医师协会营养医师分会副会长，深圳市医师协会老年医学医师分会理事，深圳市营养学会常务理事，家庭营养操作流程副主编。主持国家自然科学基金、广东省自然科学基金、市及区级科研项目共10项，作为主要完成人参与国家自然科学基金面上项目、省市级研项目、横向课题共10项。发表论文SCI论文32篇，其中第一或通讯作者论文共18篇，美国Nova 科学出版社Book Chapter一章，其他论文7篇。SCI 论文被他引 1817次，单篇论文最高被引用 663次。ESI (Essential Science Indicators) 收录高引用论文2篇.中华医学会第十四届全国肠外肠内营养学学术会议优秀论文一等奖。

一. 主持或参加科研项目及人才计划项目情况：

1. 深圳市南山区卫生健康系统科技重大项目杰出青年基金. 基于多组学-机器学习技术筛选妊娠糖尿病早期预测生物标志物的临床研究.NSZD2023024. 2023.6-2026.6.50万.主持.

2. 国家自然科学基金，82103821,原花青素通过肠道菌群-胆汁酸轴下调FXR信号通路改善妊娠糖尿病的机制研究,2022,01-2024.12.30万.主持。

3. 深圳市科创委基础研究面上项目. JCYJ20210324112400002. 基于肠道菌群--胆汁酸--FXR信号通路探讨原花青素对妊娠糖尿病的影响和机制.2021.10-2024.9,20万，在研，主持。

4. 广东省自然科学基金，2019A1515110456，黄烷醇肠道菌群代谢产物调节NLRP3炎症小体在预防妊娠糖尿病的作用及机制研究， 2020-01至2022-12，10万，结题，主持

5. 深圳市科技创新委员会2020年基础研究面上项目，黄烷醇肠道菌群依赖代谢产物与妊娠糖尿病的关系及NLRP3炎症小体介导的机制研究.JCYJ20190809102203602.2020-2022，10万,主持。

6. 广东省营养膳食与健康重点实验室开放基金，原花青素经调节肠道菌群-胆汁酸代谢对妊娠糖尿病的作用研究，2022.05-2024.05，2万，主持。

7. 深圳市南山区科技计划重点项目，201907,肠道菌群构成及短链脂肪酸与妊娠期糖尿病的关系研究，2020-2022,3万，主持。

8. 广东省医学科研基金，基于大数据探讨妊娠糖尿病新旧诊断标准对妊娠结局的影响，NO. A2017159，2017.7-2019.6. 1万，主持。

9. 深圳市卫生计生委科研项目，健康膳食模式对深圳孕妇妊娠尿病影响，No. 201402136，2014.8-2017.8，非资助，主持。

10. 南山区科技计划项目，于大数据探讨妊娠糖尿病新诊断标准应用对深圳女性妊娠结局的影响，No. 2016025，2016.11-2018.11，2.5万，主持。

11. 院内课题，术前营养风险评估及术前营养支持对肝胆外科择期手术患者术后临床结局影响的前瞻性研究,2018.8-2020.8，5万，主持。

12. 合生元母婴营养与护理研究基金项目，膳食及体内脂肪酸对妊娠糖尿病孕妇糖脂代谢变化及子代生长发育的影响及机制研究，课题主要实施者。BINCMYF19005，2019.7-2020.7，20万，第二负责人。

二、代表性科研成果

1. Yao Liu, Hengying Chen b, Yingyu Zhou, Xiaoping Lin, Lanyao Yang, Bowen Zhan,Yuanhuan Wei, Ruifang Sun, Hongguang Yang, Zheqing Zhang, Guifang Deng#.The association of serum toxic metals and essential elements during earlypregnancy with body mass index trajectory of infants during the first years:A prospective study. Ecotoxicology and Environmental Safety.2024.269.115766. (通讯作者，IF 6.8)

2. Guifang Deng1†, Hengying Chen2†, Yao Liu, Yingyu Zhou,Xiaoping Lin, Yuanhuan Wei, Ruifang Sun, Zheqing Zhang*,Zhenhe Huang*.Combined exposure to multiple essential elements and cadmium at early pregnancy on gestational diabetes mellitus: a prospective cohort study. Frontiers in Nutrition .2023 6:10:1278617. (第一作者，IF 5.0)

3. Yao Liu, Yuanhuan Wei, Lanlan Wu, Xiaoping Lin, Ruifang Sun, Hengying Chen, Siwen Shen, Guifang Deng#. Fructose Induces Insulin Resistance of Gestational Diabetes Mellitus in Mice via the NLRP3 Inflammasome Pathway Frontiers in Nutrition 2022 12;9:839174. doi: 10.3389/fnut.2022.839174. eCollection 2022. (通讯作者，IF 5.0)

4. Yao Liu, Ruifang Sun, XiaoPing Lin, Lanlan Wu, Hengying Chen, Siwen Shen,Yan Li, Yuanhuan Wei, Guifang Deng#. Procyanidins and its metabolites by gut microbiome improves insulin resistance in gestational diabetes mellitus mice model via regulating NF-κB and NLRP3 inflammasome pathway. Biomedicine & Pharmacotherapy. 2022,151: 113078. (通讯作者，IF 7.419)

5. Wu L, Sun R, Liu Y, Liu Z, Chen H, Shen S, Wei Y, Deng G#. High hemoglobin level is a risk factor for maternal and fetal outcomes of pregnancy in Chinese women: A retrospective cohort study. BMC Pregnancy Childbirth. (2022) 22:290（通讯作者，IF 3.105）

6. Lanlan Wu, Yao Liu, Zengyou Liu, Hengying Chen, Siwen Shen, Yuanhuan Wei, Ruifang Sun and Guifang Deng#. Serum urea acid and urea nitrogen levels

are risk factors for maternal and fetal outcomes of pregnancy: a retrospective cohort study. Reproductive Health. (2022) 19:192. （通讯作者，IF 3.355）

7. Lanyao Yang, Lanlan Wu, Yao Liu, Hengying Chen, Yuanhuan Wei, Ruifang Sun, Siwen Shen3,Bowen Zhan, Jianjun Yang, Guifang Deng#. Association Between Serum Ferritin Concentration and Risk of Adverse Maternal and Fetal Pregnancy Outcomes: A Retrospective Cohort Study. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 2022:15 2867–2876. （通讯作者，IF 3.249）

8. Guifang Deng, Qiucheng Lei, Xuejin Gao, Yupeng Zhang, Huazhen Zheng, Jingcheng Bi 5, Xinying Wang. Glucagon-Like Peptide-2 Modulates Enteric Paneth Cells Immune Response and Alleviates Gut Inflammation During Intravenous Fluid Infusion in Mice With a Central Catheter. Front Nutr 2021 Sep 3;8:688715. doi: 10.3389/fnut.2021.688715. eCollection 2021. (IF 5.0)

9. Yao Liu; Guifang Deng#; Xu Wang; Jing Luo; Xiaoyun Qian;Wenhua Ling . Cyanidin-3-O-β-glucoside Polarizes LPS-induced M1 into M2 Macrophage in J774 Cells via PPARγ-mediated NF-κB and STAT6 Signaling Pathway. J of Functional Foods.2021. 77.104314 （通讯作者，IF 5.223）

10. Chen H^‡, Deng G‡, Zhou Q, Chu X, Su M, Wei Y, Li L, Zhang Z. Effects of eicosapentaenoic acid and docosahexaenoic acid versus α-linolenic acid supplementation on cardiometabolic risk factors: a meta-analysis of randomized controlled trials. Food Funct. 2020;11(3):1919-1932.(并列第一作者，IF 6.317)

11. Yan Li,* Tingwei Yu,* Zengyou Liu, Hengying Chen, et al. Guifang Deng#, Zheqing Zhang #. Association of Serum Uric Acid, Urea Nitrogen, and Urine Specific Gravity Levels at 16–18 Weeks of Gestation with the Risk of Gestational Diabetes Mellitus. Diabetes Metabolic Syndrome and Obesity- Targets and Therapy 2020:13:4689-4697（IF3.249，通讯作者）

12. YaoLiu,RuifangSun,YanLi,HengyingChen,LanlanWu,SiwenShen,YuanhuanWei,NuoyaWang,ZheqingZhang,ZengyouLiu,GuifangDeng#.Changes in serum total bile acid concentrations are associated with the risk of developing adverse maternal and perinatal outcomes in pregnant Chinese women. Clinica Chimica Acta.2021.520: 160-167.（IF6.314，通讯作者）

13. Hengying Chen,Zheqing Zhang,Yingyu Zhou,Yao Liu,Xiaoping Lin,Yuanhuan Wei,Ruifang Sun,Liping Li,Guifang Deng.Maternal leucocyte trajectory across pregnancy associated with offspring's growth. Pediatric Research.2022 Sep;92(3):862-870.（IF 3.933，并列通讯作者）

14. 孙瑞方，吴兰兰，刘 瑶，韦远欢，沈思文，王诺亚，简西廷，邓桂芳.加速康复外科围手术期营养管理对儿童耳鼻喉外科病人临床结局的影响. 肠外与肠内营养.2022.29(6).342-346.

15. Li Zhang, Siwen Wang, Xuejin Gao , Tingting Gao , Lingli Huang , Bo Lian , Yingchao Gu , Jianjiao Chen, Dong Guo , Zhenyi Jia, Yong Wang , Fangyou Gong, Junde Zhou, Zhigang Xue, Zhida Chen, Jielian Xu, Leilei Wang, Jun Qian , Guifang Deng, Hao Hu, Yao Nie, Gang Li , Mengbin Li , Hua Yang , Wei Zhao , Yanbing Zhou, Huanlong Qin , Xiaoting Wu, Kunhua Wang, Qiang Chi , Jianchun Yu, Yun Tang, Pianhong Zhang, Gang Jin, Bin Ouyang, Guoli Li , Dong Hang and Xinying Wang. Frontiers in Nutrition. 2022.9:850063. (IF 6.591)

16. Chen Gengdong, Li Yan, Zeng Fangfang, Deng, Guifang, Liang Jingjing,Wang Jue; Su Yixiang, Chen Yuming, Mao Limei, Liu Zhengping, Bao Wei, Zhang, Zheqing. Biomarkers of fatty acids and risk of type 2 diabetes: a systematic review and meta-analysis of prospective cohort studies. Critical reviews in food science and nutrition. 2020. 10.1080/10408398.2020.1784839.（IF 11.208）

17. Gengdong Chen, Yan Li, Guifang Deng, Shiksha Shrestha, Fengyan Chen, Yuanhuan Wei, Zhaochang Huang, Jialiang Pan, Zheqing Zhang. Associations of Plasma Copper, Magnesium, and Calcium Levels With Blood Pressure in Children: A Cross-sectional Study. Biological Trace Element Research.2020. doi: 10.1007/s12011-020-02201-z.（IF 4.081）

18. Deng Gui-Fang, Nie Lei, Ai Wen, Wei Yuan-Huan, Sun Rui-Fang, Deng Xiu-Juan, Li Hua-Bin. Effects of Simulated Gastrointestinal Digestion on Antioxidant Activities of Individual and Mixed Fruits. North American Journal of Medicine and Science.2019.12(1):14-20.

19. 李艳,韦远欢,陈凤燕,陈耿东,王晴柔,张喆庆#,邓桂芳#.广州市 6-9 岁儿童脂肪分布与妊娠期糖尿病的关联研究.中国学校卫生.2020

20. 邓桂芳 ，李翠玉，韦远欢 ，王新颖. 术前口服营养补充对消化道恶性肿瘤病人营养状况及临床结局的影响. 肠外与肠内营养.2019.26(4).208-211.

21. 邓桂芳，韦远欢，黄丽葵，叶燕嫦. 妊娠期糖尿病系统化家庭管理对母婴临床结局的影响.海南医学. 2019.30(12).1-4.

22. 聂雷，周颖，邓桂芳*，池莲祥.深圳地区城市居民腰围与血清胰岛素水平关系的临床研究. 广西医科大学学报.2018.35（10）:1414-1417.

23. Mo, Ronghui, Liu Hongxu, Lai, Ritian, Deng, Guifang, Zhang Zheqing, Pei Zezhen, Li Huabin, Xia Enqin. Ultrasound-Assisted Upper Liquid Micro- extraction Coupled to Molecular Fluorescence for Detection of Bisphenol A in Commercial Beverages. Food Analytical Methods.2017.10: 1575-1581.（IF 3.498）

24. 聂雷，邓桂芳，钟丽娣，池莲祥*.血清25羟基维生素D水平与糖代谢异常的关系探讨.海南医学.2017.1023-1026.

25. 邓桂芳，韩金玲，邓小荣，谢有志，孙瑞方. 长期单瓶补充肠外营养致Wernicke脑病一例. 海南医学. 2017.28.770-773.

26. Deng GF，Xu DP，Li S，Li HB*. Optimization of Ultrasound-Assisted Extraction of Natural Antioxidants from Sugar Apple (Annona squamosa L.) Peel Using Response Surface Methodology，Molecules，2015，20（11）：20448-20459. (IF 4.927)

27. Deng GF, Xu XR, Zhang Y, Li D, Gan RY, Li HB*. Phenolic compounds and bioactivities of pigmented rice. Critical Reviews in Food Science and Nutrition, 2013, 53: 296-306. (IF 11.208)

28. Deng GF, Lin X, Xu XR, Gao LL, Xie JF, Li HB*. Antioxidant capacities and total phenolic contents of 56 vegetables. Journal of Functional Foods, 2013, 5: 260-266. (IF 5.223)

29. Deng GF, Xu XR, Guo YJ, Ling WH, Li HB*. Determination of antioxidant property and their  lipophilic and hydrophilic phenolic contents in cereal grains. Journal of Functional Foods. 2012. 4: 906 – 914. (IF 5.223)

30. Deng GF, Shen C, Xu XT, Ling WH, Li HB*. Potential of Fruit Wastes as Natural Resources of Bioactive Compounds. International Journal of Molecular Sciences, 2012, 13: 8308-8323.  (IF 6.208)

31. Deng GF, Li K, Ma J, Liu F, Dai JJ, Li HB*. Aluminium content of some processed foods, raw materials and food additives in China by inductively coupled plasma–mass spectrometry. Food Additives and Contaminants: Part B, 2011,4: 248–253. (IF 3.964)

32. Guo YJ, Deng GF #, Xu XR, Wu S, Li S, Xia EQ, Li F, Chen F, Ling WH, Li HB*. Antioxidant capacities, phenolic compounds and polysaccharide contents of 49 edible macro-fungi. Food & Function, 2012. 3: 1195-1205. (IF 6.317)

33. Song Y, Deng GF #, Xu XR, Chen YH, Chen F, Li HB. Nitrate and nitrite content in bottled beverages by ion-pair high-performance liquid chromatography. Food Additives and Contaminants: Part B, 2013, 6:42-46. (IF 3.964)

34. Deng GF, Xu XR, Li S, Li F, Wu S, Li HB*. Natural Antioxidant In Food. In: Phytochemicals: Occurrence in Nature, Health Effects and Antioxidant Properties. Kuang Haixue (ed.), Nova Science Publishers Inc., New York, NY, USA. 2013, pp. 147-174.

35. Li Fang, Li Sha, Li Hua-Bin, Deng Gui-Fang, Ling Wen-Hua, Xu Xiang-Rong. Antiproliferative activities of tea and herbal infusions. Food& Function, 2013, 4, 530-538. (IF 6.317)

36. Xia En-Qin, Deng Gui-Fang, Guo Ya-Jun, Li Hua-Bin. Biological activities of polyphenols from grapes. International Journal of Molecular Sciences, 2010, 11: 622-646. (IF 6.208)

37. Fang Li, Sha Li, Hua-Bin Li, Gui-Fang Deng, Wen-Hua Ling, Shan Wu, Xiang-Rong Xu, Feng Chen. Antiproliferative activity of peels, pulps and seeds of 61 fruits. Journal of Functional Foods, 5(3), 2013, 1298–1309. (IF 5.223)

38. Xia En-Qin, Yu Ying-Ying, Xu Xiang-Rong, Deng Gui-Fang, Guo Ya-Jun, Li Hua-Bin. Ultrasound-assisted extraction of oleanolic acid and ursolic acid from Ligustrum lucidum Ait. Ultrasonics Sonochemistry. 2012.19: 772–776. (IF 9.336)

39. Chen Yong-Hong, Xia En-Qin, Xu Xiang-Rong, Ling Wen-Hua, Li Sha, Wu Shan, Deng Gui-Fang,  Zou Zhi-Fei, Zhou Jing, Li Hua-Bin. Evaluation of Acrylamide in Food from China by a LC/MS/MS Method. International Journal of Environmental Research and Public Health, 2012. 9: 4150-4158. (IF 4.614)

40. Chen Yong-Hong, Xia En-Qin, Xu Xiang-Rong, Li Sha, Ling Wen-Hua, Wu Shan, Deng Gui-Fang, Zou Zhi-Fei, Zhou Jing, Li Hua-Bin. Evaluation of Benzo[a]pyrene in Food from China by High-Performance Liquid Chromatography-Fluorescence Detection. International Journal of Environmental Research and Public Health, 2012, 9: 4159-4169. (IF 4.614)

41. Li, Sha; Li, Shu-Ke; Li, Hua-Bin; Xu, Xiang-Rong; Deng, Gui-Fang; Xu, Dong-Ping Processing and Impact on Antioxidants in Beverages. Antioxidant Capacities of Herbal Infusions. Preedy, V.2014,41-50.